A redesigned CD40 immunotherapy delivered directly into tumors triggered powerful immune responses in a small clinical trial, shrinking tumors in half the patients and completely eliminating cancer in two. Even tumors that weren’t injected disappeared, hinting that the treatment can spark a body-wide immune attack. Credit: AI/ScienceDaily.com For more than two decades, scientists have explored a group of cancer drugs known as CD40 agonist antibodies. Early experiments suggested these treatments