University of Surrey Mar 16 2026 A metabolic enzyme studied for over seven decades has a hidden second function - it can unwind RNA and promote cell cycle progression, an additional function beyond its role in energy production, according to a new study led by the University of Surrey. Phosphofructokinase (PFK) is the 'gatekeeper' of glycolysis, the ancient and evolutionarily conserved metabolic pathway that breaks down sugar to generate energy. In the yeast Saccharomyces cerevisiae, PFK is