There are concerns coming from the US. A tragic but not unexpected case has been reported in Louisiana, where the first death associated with the H5N1 virus in the United States has been confirmed by health authorities. The patient, a man over 65 years old with underlying health conditions, was infected after contact with poultry and wild birds. • Epidemiological Background This case represents a worrying moment in a year in which the US has been facing a widespread bird flu outbreak, affecting