Wyss Institute for Biologically Inspired Engineering at Harvard Jul 2 2025 Rett syndrome is a devastating rare genetic childhood disorder primarily affecting girls. Merely 1 out of 10,000 girls are born with it and much fewer boys. It is caused by mutations in the MeCP2 gene on the X chromosome, leading to a spectrum of cognitive and physical impairments, including repetitive hand motions, speech difficulties, and seizures.  However, besides severe impairment of neurological functions, which