Jun 13 2025 Major depressive disorder (MDD) is a mental health condition that negatively affects the mood of a person and causes a loss of interest in activities that were previously associated with happiness. In addition to cognitive impairments and forgetfulness, MDD can significantly affect social and occupational areas of functioning. Studies investigating the pathophysiology of MDD indicate that several immune factors and cells-such as brain glial cells-play a key role in driving