Xia & He Publishing Inc. Jan 24 2026 Familial Hypobetalipoproteinemia (FHBL), caused by variants in the apolipoprotein B (APOB) gene, is a rare autosomal co-dominant monogenic disorder characterized by lifelong low plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and APOB. While FHBL is considered cardioprotective due to lifelong low LDL-C, recent evidence highlights its strong association with liver disease, positioning it as a unique monogenic model for