InSilico Medicine Jul 4 2025 Aberrations in fibroblast growth factor receptors FGFR2/3 are major drivers of many cancers-including intrahepatic cholangiocarcinoma, endometrial, breast, gastric, and bladder cancers. However, the development of selective inhibitors targeted FGFR2/3 has long been challenged by the high sequence and structural similarity among FGFR family members, particularly the binding pocket homology among FGFR1, FGFR2, and FGFR3 exceeds 95%. Currently approved pan-FGFR