RNA quality control protein PELOTA found to slow aging and extend lifespan
DNA
KAIST (Korea Advanced Institute of Science and Technology) Aug 18 2025 As aging progresses, the quality of DNA and proteins inside cells declines, known to be the cause of various degenerative diseases. However, the connection between aging and RNA has remained largely unexplored. Now, a Korean research team has discovered that a ribosome-associated quality control factor—PELOTA, a protein essential for eliminating abnormal mRNA—plays a central role in slowing aging and promoting longevity.
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