Viruses may hold the blueprint for next-generation antibiotics—by revealing how to shut down a bacterial lifeline called MurJ. Here, three distinct phage Sgl proteins lock the flippase MurJ in an outward-facing state, providing a template for antibiotic discovery. Credit: Juliet Lee Scientists have revealed how viruses that infect bacteria shut down MurJ, a protein essential for building the bacterial cell wall. Remarkably, different viruses evolved separate proteins that all block MurJ in the

Tag-uri: Medicamente