Autoantibodies against vinculin linked to childhood kidney disease
Teona Gherasim
Research by Science Partner Journal Jun 19 2025 Idiopathic nephrotic syndrome (INS) is a serious kidney disease in children with no clear cause. In a recent study, researchers have identified a novel autoantibody targeting vinculin—a protein crucial for kidney cell structure—as a significant factor in INS. The study found that these autoantibodies are present during active diseases and decline when symptoms subside, suggesting potential for diagnosis and disease monitoring. Mouse models were
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