Around 10 percent of people who take statins to lower cholesterol experience mysterious muscle pains, causing many to discontinue these potentially life-saving medicines. Now, researchers from Columbia University and the University of Rochester in the US have revealed that statin-associated muscle symptoms (SAMS), such as aches and fatigue, result from an influx of calcium into muscle cells, which leads to tissue damage and potentially life-threatening complications. Statins work by blocking an